The Science of Living Better, Longer
Modern research shows we can’t stop aging, but we can slow it. By studying cells, metabolism, and genetics, science is uncovering real ways to extend vitality and add more healthy years to life.
The 5 Pillars of Longevity
Nutrition
Plant-rich diet and fasting boost metabolism and cell health.
Movement
Cardio, strength, and recovery keep heart, muscles, and immunity strong.
Rest & Sleep
Deep sleep and stress balance drive regeneration.
Social Bonds
Purpose and positive relationships add healthy years.
Prevention
Check-ups and proactive care protect long-term health.
12 HALLMARKS OF AGING
Genomic Instability
Over time, DNA damage builds up in our cells, weakening their ability to function and repair themselves.
Genomic Instability
Over time, DNA damage builds up in our cells, weakening their ability to function and repair themselves.
Telomere Shortening
Each cell division trims the protective ends of our chromosomes. When they become too short, cells stop dividing
Telomere Shortening
Each cell division trims the protective ends of our chromosomes. When they become too short, cells stop dividing
Epigenetic Shifts
Changes in how our genes are switched on or off alter cell behavior and gradually erode their identity.
Epigenetic Shifts
Changes in how our genes are switched on or off alter cell behavior and gradually erode their identity.
Loss of Proteostasis
Proteins can fold incorrectly or break down, and when the cleanup systems fail, they accumulate and stress the cell.
Loss of Proteostasis
Proteins can fold incorrectly or break down, and when the cleanup systems fail, they accumulate and stress the cell.
Imbalanced Nutrient Sensing
As cells age, they become increasingly unable to correctly detect nutrients and energy signals, and they respond inaccurately. As a result, central metabolic pathways such as Insulin/IGF-1, mTOR, AMPK, and sirtuins become imbalanced.
Imbalanced Nutrient Sensing
As cells age, they become increasingly unable to correctly detect nutrients and energy signals, and they respond inaccurately. As a result, central metabolic pathways such as Insulin/IGF-1, mTOR, AMPK, and sirtuins become imbalanced.
Mitochondrial Decline
The “power plants” of the cell produce less energy and more free radicals with age, driving damage and inflammation.
Mitochondrial Decline
The “power plants” of the cell produce less energy and more free radicals with age, driving damage and inflammation.
Cellular Senescence
Aged cells stop multiplying but linger, releasing inflammatory factors that disrupt healthy tissue.
Cellular Senescence
Aged cells stop multiplying but linger, releasing inflammatory factors that disrupt healthy tissue.
Stem Cell Fatigue
Stem cells lose their vigor, making it harder for the body to renew and repair itself.
Stem Cell Fatigue
Stem cells lose their vigor, making it harder for the body to renew and repair itself.
Communication Breakdown
Cells send more damaging signals as we age, which amplifies inflammation and tissue decline.
Communication Breakdown
Cells send more damaging signals as we age, which amplifies inflammation and tissue decline.
Chronic Inflammation
Low-grade, persistent inflammation becomes widespread with age and fuels many age-related conditions.
Chronic Inflammation
Low-grade, persistent inflammation becomes widespread with age and fuels many age-related conditions.
Weakened Immunity
The immune system grows less effective at fighting infections and can mistakenly attack the body’s own tissues.
Weakened Immunity
The immune system grows less effective at fighting infections and can mistakenly attack the body’s own tissues.
Structural Decline
Bones, skin, and vessels gradually lose strength and flexibility, reducing overall resilience.
Structural Decline
Bones, skin, and vessels gradually lose strength and flexibility, reducing overall resilience.
“Longevity and skincare go hand in hand, you can´t think of one without the other.”
Harnessing Nature
to Slow Aging
Modern longevity research shows that certain natural compounds can directly support cellular health and influence the hallmarks of aging. By reducing oxidative stress, protecting DNA, and improving energy production, these ingredients offer real potential to extend vitality and resilience.
Active ingredients that matter.
Rhodiola rosea and Longevity
Rhodiola rosea is a small plant that grows in the colder northern regions of Europe and Asia.Rhodiola rosea has been used for centuries as an adaptogen to help people adapt to physical and mental stress.
- Rhodiola rosea extends the lifespan of various organisms.
- Rhodiola rosea increases the production of proteins that protect cells from damage.
- Rhodiola improves mitochondrial health.
- Rhodiola rosea activates SIRT and AMPK, important regulators of a healthy metabolism.
- Rhodiola can inhibit mTOR, a key aging switch.
- A substance found in Rhodiola rosea, salidroside, can improve nerve regeneration.
- Rhodiola rosea can protect the brain from damage and neurotoxins.
- Rhodiola rosea can improve memory, concentration, and learning in humans.
- Rhodiola rosea can boost energy and reduce fatigue in humans.
How Rhodiola rosea may slow the aging process
Rhodiola rosea can influence the aging process in several ways. For example, Rhodiola rosea can upregulate defense and repair proteins in the cell, such as chaperone proteins. Chaperones protect proteins in the cell from damage by forming a “protective shield” around them.
Rhodiola rosea also improves mitochondrial health. In addition, taking Rhodiola can upregulate SIRT1 and AMPK, important proteins involved in longevity.
Studies have found that Rhodiola inhibits mTOR, a key aging switch, and can stimulate autophagy in cells.
Autophagy is a process through which cells get rid of proteins that would otherwise accumulate and eventually harm cells and organs.
As we get older, autophagy becomes less efficient, and more proteins accumulate in our cells, contributing to the aging process.
Regenerative compounds in Rhodiola – Salidroside and Rosavin
Two specific compounds in Rhodiola rosea have received significant attention
— salidroside and rosavin.
Salidroside appears to have neuroprotective effects and may even improve nerve regeneration.
A particular variety of Rhodiola was able to enhance the formation of new neurons in rats exposed to a strong neurotoxin.
Conclusion
Rhodiola rosea is a true natural talent when it comes to stress, mental exhaustion, and energy balance. Its traditional use is now supported by modern research — making Rhodiola an exciting ally for anyone seeking more balance and focus in a fast-paced daily life.
Resveratrol and longevity
Resveratrol is a natural plant substance that is mainly found in red grapes, berries and peanuts. In recent years, it has been studied intensively for its potential health-promoting effects, particularly in connection with longevity.
Resveratrol acts as an antioxidant and is said to have cell-protecting effects. Of particular interest is its ability to activate so-called sirtuins - enzymes that are associated with the regulation of cell ageing and metabolic processes. Studies on animals show that under certain conditions resveratrol can trigger effects similar to calorie restriction, a known mechanism for prolonging life.
David Sinclair, one of the world's best-known ageing researchers and professor at Harvard Medical School, is one of the most prominent proponents of resveratrol. In his publications - particularly in his book “Lifespan: Why We Age - and Why We Don't Have To” - he describes resveratrol as one of the most promising substances for activating so-called “longevity genes”, especially the sirtuins.
What exactly does Sinclair say about Resveratrol?
- Activation of sirtuins According to Sinclair, resveratrol activates the enzyme SIRT1, which plays a key role in cell repair, metabolism and ageing regulation. He often compares the effect of resveratrol to that of calorie restriction - one of the few known ways to extend lifespan in animal studies.
- Resveratrol + NMN = dream team? Sinclair emphasizes that resveratrol may be particularly effective in combination with other molecules such as NMN (nicotinamide mononucleotide), as the two affect different pathways of cellular energy supply and longevity.
- Taking it yourself: Sinclair says he has been taking resveratrol daily for years (about 1 gram in the morning, together with some fat, because it is fat-soluble). However, he emphasizes that he is not making any medical recommendations and that more research is needed.
- Criticism and caution Even if Sinclair is very optimistic, there is also criticism: some other scientists point out that the effect in humans has not yet been clearly proven and that early hopes were partly exaggerated. Even Sinclair now frequently emphasizes that resveratrol is part of a larger puzzle - not the sole solution.
Conclusion
For David Sinclair, Resveratrol is an exciting part of his personal anti-aging strategy. He sees it as a potential means of activating the body's own protective mechanisms, but also warns that it is not a miracle cure - but rather a possible building block for a longer, healthier life.
Quercetin - plant power for health
Quercetin is a naturally occurring plant substance, more precisely a so-called flavonoid. It is found in many foods that we eat regularly: Onions, apples, berries, kale, grapes and green tea are particularly rich in it. A certain amount is also found in red wine - which makes quercetin one of the many “secrets” of the Mediterranean diet.
Effects and benefits
Quercetin is particularly valued for its antioxidant, anti-inflammatory and immune-boosting properties. It helps the body to neutralize so-called free radicals - aggressive molecules that damage our cells and are associated with ageing processes and chronic diseases.
Effects of Quercetin
- Anti-inflammatory properties Quercetin can dampen certain inflammatory processes in the body, which could be helpful in cases of autoimmune diseases or allergies, for example.
- Immune system booster Studies suggest that quercetin strengthens the body's defenses - especially in combination with vitamin C.
- Antiviral effects
- There is evidence that quercetin can inhibit the reproduction of some viruses - including influenza viruses and coronaviruses.
- Lowering blood pressure and protecting the heart
- Some studies show that quercetin can have a slight blood pressure-lowering effect and has a positive effect on vascular health.
- Possible anti-ageing effect In ageing research, quercetin is being discussed together with the active ingredient dasatinib as a so-called “senolytic” - i.e. as an agent that recognizes and removes ageing cells.
Studies
Scientific research on quercetin is promising, but not quite there yet. In laboratory and animal studies, quercetin shows clear effects against inflammation, oxidative stress and even certain cancer cells. Initial clinical studies on humans also indicate positive effects - for example in the treatment of high blood pressure, viral infections or chronic inflammation.
However, the bioavailability of quercetin is an issue: it is only absorbed by the body to a limited extent. Researchers are therefore working on special forms (e.g. liposomal quercetin or in combination with fats or other substances) to improve its effectiveness.
Conclusion
Quercetin is an exciting plant substance with many health-promoting properties. It has an antioxidant and anti-inflammatory effect and can strengthen the immune system. Although research is not yet complete, initial results are positive.
Ashwagandha - the power root from Ayurveda
Ashwagandha, also known as “sleep berry” or Withania somnifera, is a medicinal plant that has been used in Ayurvedic medicine for over 3,000 years. The name translates roughly as “smell of the horse” - this is not only a reference to the earthy smell of the root, but also to the invigorating effect it is said to have.
Origin and use
Ashwagandha originally comes from India, Africa and the Middle East. In traditional Ayurvedic teachings, it is considered an adaptogen - in other words, it is said to help the body to cope better with stress and restore inner balance. The root is usually used, but the leaves are also rarely used.
Effects and benefits
The effects of ashwagandha are manifold and are particularly useful in stressful, nervous phases:
- Stress reduction & cortisol lowering - studies show that ashwagandha can lower cortisol levels - the main stress hormone. Many report better sleep, more serenity and inner peace.
- Sleep quality - The plant is traditionally used for sleep problems - especially for stress-related restlessness or difficulty falling asleep.
- Concentration & cognitive performance - There is evidence that ashwagandha can improve memory and attention - especially in people under stress.
- Boosting libido & fertility - Some studies have shown a positive effect on testosterone levels, sperm quality and sexual energy - in both men and women.
- Anti-inflammatory & antioxidant effects - Like many plant substances, ashwagandha can also fight free radicals and have an anti-inflammatory effect.
Studies
Modern research confirms many of the traditional applications. The stress-reducing effect has been particularly well investigated - randomized studies have shown that ashwagandha can significantly reduce stress and anxiety when taken regularly - in some cases comparable to mild medication, but without the typical side effects.
There is also promising data for sleep disorders, mild depression and to support cognitive performance. However, not every effect has yet been proven in large long-term studies - but the trend in research is clearly positive.
Conclusion
Ashwagandha is more than just a trend - it is a powerful medicinal plant with a long tradition and growing scientific support. Whether for calming in stressful times, for better sleep or as a natural energy booster, the root has many potential uses. If you want to rely on herbal support, ashwagandha is a proven companion.
NMN
Nicotinamide mononucleotide – NMN – is a naturally occurring molecule found in every living cell of all life forms. On a molecular level, it belongs to the class of nucleotides, the building blocks of RNA and DNA.
NMN is directly converted into nicotinamide adenine dinucleotide – NAD+ – and therefore increases NAD+ levels. For this reason, NMN is also referred to as an NAD+ booster.
Effects and Benefits
- Energy metabolism: NMN increases NAD+ levels, which supports the function of mitochondria—the cell’s powerhouses—and facilitates the conversion of food into energy.
- Metabolism:It may promote fat metabolism and improve insulin sensitivity, which can contribute to weight management.
- Cognitive function:Studies suggest that NMN can improve brain function.
- Cardiovascular health:NMN may support circulation and overall heart health.
- DNA repair and longevity:NMN activates sirtuins, which play a role in DNA repair and longevity.
- Muscle function: Clinical studies show that NMN can improve muscle strength and walking speed in older men.
- Skin health: In cosmetics, NMN is used for its potential to reduce wrinkles and improve skin texture.
How much NMN?
Considering efficacy and safety studies in humans and animals, as well as calculations of optimal NMN dosage, the recommended daily dose for adults between 30 and 60 years is 500 mg.
People over 65 can safely take 750 mg daily to maximise the benefits of NMN.
Conclusion
Studies confirm that NMN lengthens telomeres, rejuvenates stem cells, and reduces biological age. Taking NMN is a promising way to combat age-related diseases and conditions.
Ergothioneine
L-Ergothioneine is a unique naturally occurring amino acid produced by mushrooms, yeasts, and certain types of bacteria.
What makes it special is that it behaves in the human body similarly to a vitamin. Vitamins are essential for us because our bodies cannot produce them on their own, yet they are needed for important biochemical reactions.
Ergothioneine acts as a powerful antioxidant and anti-inflammatory agent that protects cells from oxidative stress. For this reason, it is often referred to as the “longevity vitamin.” Studies have shown that ergothioneine levels decline as part of the aging process.
Effects and Benefits
- Antioxidant activity: Neutralises harmful free radicals (ROS) and binds pro-oxidative metals, preventing cellular damage.
- Anti-inflammatory effects: Inhibits inflammatory mediators, helping reduce inflammation.
- Cell protection: Protects cells from damage caused by oxidative stress.
- Anti-aging / Longevity support: Promotes longevity, may slow down the aging process, and protects internal organs from age-related damage.
- Skin protection: Protects the skin from UV damage, supports repair, and helps maintain moisture.
- Eye protection: Shields the lens and cornea from oxidative stress caused by UV radiation and may help prevent cataracts.
- Cognitive support: Because ergothioneine can cross the blood-brain barrier, it may have beneficial effects on the brain and support overall cognitive health.
- Metabolic support: May help promote the formation of NAD⁺, a coenzyme associated with longevity.
Conclusion
A vital compound that supports cellular function, brain health, and healthy longevity.
Magnesium Bisglycinate
Magnesium bisglycinate is an essential molecule for the functioning and support of the nervous system.
Magnesium bisglycinate is known for its very high bioavailability and excellent tolerability. Its main benefits include promoting relaxation, supporting the nervous system, and improving sleep quality.
Effects and Benefits
- Relaxation and sleep:It is particularly effective for stress and sleep disorders. Magnesium regulates neurotransmitters such as GABA (gamma-aminobutyric acid), which help calm the nervous system and promote a state of relaxation, making it easier to fall asleep and improving sleep quality.
- Nerve function and stress management: Because the compound of magnesium and the amino acid glycine can cross the blood–brain barrier, it directly supplies the nervous system. This helps reduce nervousness, irritability, and inner restlessness.
- Muscle health: Magnesium is essential for normal muscle function. Magnesium bisglycinate can help relieve muscle cramps and tension.
- Stomach-friendly:Compared to other forms of magnesium, such as magnesium citrate, magnesium bisglycinate is very well tolerated and gentle on the digestive system, making it a great choice for people with sensitive stomachs.
- Cardiovascular health: It supports heart health by regulating blood pressure and helping maintain healthy blood vessels.
Conclusion
In summary, magnesium bisglycinate — thanks to its high absorption and targeted action on the nervous system — is ideal for people dealing with stress, sleep problems, or those seeking a highly tolerable form of magnesium.
Taurine
Taurine is an amino acid that performs many important functions in the body, such as supporting heart health, stabilising cell membranes, and promoting fat digestion. It also acts as a strong antioxidant, detoxifying and anti-inflammatory agent, and supports the development of the brain and nervous system.
Effects and Benefits
- Heart health: Supports a regular heartbeat and influences signal transmission and the development of the heart.
- Nervous system: Acts as a neurotransmitter in the brain, protects nerve cells, has a calming effect, and is involved in the healthy development of the central nervous system.
- Digestion: Plays a role in the formation of bile acids, thereby supporting fat digestion and the absorption of fat-soluble vitamins (A, D, E, K).
- Antioxidant effects: Protects cells from free radicals and oxidative stress.
- Cell function: Helps stabilise cell membranes and regulates the influx of minerals such as calcium into cells.
- Immune system: Stimulates and supports immune function.
- Development: Important for the healthy development of the retina and photoreceptors.
Conclusion
A deficiency can lead to increased susceptibility to infections and other issues, such as growth disorders in children, weakened immunity, or retinal degeneration. As we age, taurine concentrations in the body decrease.
Rhodiola rosea and Longevity
Rhodiola rosea is a small plant that grows in the colder northern regions of Europe and Asia.Rhodiola rosea has been used for centuries as an adaptogen to help people adapt to physical and mental stress.
- Rhodiola rosea extends the lifespan of various organisms.
- Rhodiola rosea increases the production of proteins that protect cells from damage.
- Rhodiola improves mitochondrial health.
- Rhodiola rosea activates SIRT and AMPK, important regulators of a healthy metabolism.
- Rhodiola can inhibit mTOR, a key aging switch.
- A substance found in Rhodiola rosea, salidroside, can improve nerve regeneration.
- Rhodiola rosea can protect the brain from damage and neurotoxins.
- Rhodiola rosea can improve memory, concentration, and learning in humans.
- Rhodiola rosea can boost energy and reduce fatigue in humans.
How Rhodiola rosea may slow the aging process
Rhodiola rosea can influence the aging process in several ways. For example, Rhodiola rosea can upregulate defense and repair proteins in the cell, such as chaperone proteins. Chaperones protect proteins in the cell from damage by forming a “protective shield” around them.
Rhodiola rosea also improves mitochondrial health. In addition, taking Rhodiola can upregulate SIRT1 and AMPK, important proteins involved in longevity.
Studies have found that Rhodiola inhibits mTOR, a key aging switch, and can stimulate autophagy in cells.
Autophagy is a process through which cells get rid of proteins that would otherwise accumulate and eventually harm cells and organs.
As we get older, autophagy becomes less efficient, and more proteins accumulate in our cells, contributing to the aging process.
Regenerative compounds in Rhodiola – Salidroside and Rosavin
Two specific compounds in Rhodiola rosea have received significant attention
— salidroside and rosavin.
Salidroside appears to have neuroprotective effects and may even improve nerve regeneration.
A particular variety of Rhodiola was able to enhance the formation of new neurons in rats exposed to a strong neurotoxin.
Conclusion
Rhodiola rosea is a true natural talent when it comes to stress, mental exhaustion, and energy balance. Its traditional use is now supported by modern research — making Rhodiola an exciting ally for anyone seeking more balance and focus in a fast-paced daily life.
Quercetin - plant power for health
Quercetin is a naturally occurring plant substance, more precisely a so-called flavonoid. It is found in many foods that we eat regularly: Onions, apples, berries, kale, grapes and green tea are particularly rich in it. A certain amount is also found in red wine - which makes quercetin one of the many “secrets” of the Mediterranean diet.
Effects and benefits
Quercetin is particularly valued for its antioxidant, anti-inflammatory and immune-boosting properties. It helps the body to neutralize so-called free radicals - aggressive molecules that damage our cells and are associated with ageing processes and chronic diseases.
Effects of Quercetin
- Anti-inflammatory properties Quercetin can dampen certain inflammatory processes in the body, which could be helpful in cases of autoimmune diseases or allergies, for example.
- Immune system booster Studies suggest that quercetin strengthens the body's defenses - especially in combination with vitamin C.
- Antiviral effects
- There is evidence that quercetin can inhibit the reproduction of some viruses - including influenza viruses and coronaviruses.
- Lowering blood pressure and protecting the heart
- Some studies show that quercetin can have a slight blood pressure-lowering effect and has a positive effect on vascular health.
- Possible anti-ageing effect In ageing research, quercetin is being discussed together with the active ingredient dasatinib as a so-called “senolytic” - i.e. as an agent that recognizes and removes ageing cells.
Studies
Scientific research on quercetin is promising, but not quite there yet. In laboratory and animal studies, quercetin shows clear effects against inflammation, oxidative stress and even certain cancer cells. Initial clinical studies on humans also indicate positive effects - for example in the treatment of high blood pressure, viral infections or chronic inflammation.
However, the bioavailability of quercetin is an issue: it is only absorbed by the body to a limited extent. Researchers are therefore working on special forms (e.g. liposomal quercetin or in combination with fats or other substances) to improve its effectiveness.
Conclusion
Quercetin is an exciting plant substance with many health-promoting properties. It has an antioxidant and anti-inflammatory effect and can strengthen the immune system. Although research is not yet complete, initial results are positive.
NMN
Nicotinamide mononucleotide – NMN – is a naturally occurring molecule found in every living cell of all life forms. On a molecular level, it belongs to the class of nucleotides, the building blocks of RNA and DNA.
NMN is directly converted into nicotinamide adenine dinucleotide – NAD+ – and therefore increases NAD+ levels. For this reason, NMN is also referred to as an NAD+ booster.
Effects and Benefits
- Energy metabolism: NMN increases NAD+ levels, which supports the function of mitochondria—the cell’s powerhouses—and facilitates the conversion of food into energy.
- Metabolism:It may promote fat metabolism and improve insulin sensitivity, which can contribute to weight management.
- Cognitive function:Studies suggest that NMN can improve brain function.
- Cardiovascular health:NMN may support circulation and overall heart health.
- DNA repair and longevity:NMN activates sirtuins, which play a role in DNA repair and longevity.
- Muscle function: Clinical studies show that NMN can improve muscle strength and walking speed in older men.
- Skin health: In cosmetics, NMN is used for its potential to reduce wrinkles and improve skin texture.
How much NMN?
Considering efficacy and safety studies in humans and animals, as well as calculations of optimal NMN dosage, the recommended daily dose for adults between 30 and 60 years is 500 mg.
People over 65 can safely take 750 mg daily to maximise the benefits of NMN.
Conclusion
Studies confirm that NMN lengthens telomeres, rejuvenates stem cells, and reduces biological age. Taking NMN is a promising way to combat age-related diseases and conditions.
Magnesium Bisglycinate
Magnesium bisglycinate is an essential molecule for the functioning and support of the nervous system.
Magnesium bisglycinate is known for its very high bioavailability and excellent tolerability. Its main benefits include promoting relaxation, supporting the nervous system, and improving sleep quality.
Effects and Benefits
- Relaxation and sleep:It is particularly effective for stress and sleep disorders. Magnesium regulates neurotransmitters such as GABA (gamma-aminobutyric acid), which help calm the nervous system and promote a state of relaxation, making it easier to fall asleep and improving sleep quality.
- Nerve function and stress management: Because the compound of magnesium and the amino acid glycine can cross the blood–brain barrier, it directly supplies the nervous system. This helps reduce nervousness, irritability, and inner restlessness.
- Muscle health: Magnesium is essential for normal muscle function. Magnesium bisglycinate can help relieve muscle cramps and tension.
- Stomach-friendly:Compared to other forms of magnesium, such as magnesium citrate, magnesium bisglycinate is very well tolerated and gentle on the digestive system, making it a great choice for people with sensitive stomachs.
- Cardiovascular health: It supports heart health by regulating blood pressure and helping maintain healthy blood vessels.
Conclusion
In summary, magnesium bisglycinate — thanks to its high absorption and targeted action on the nervous system — is ideal for people dealing with stress, sleep problems, or those seeking a highly tolerable form of magnesium.
Resveratrol and longevity
Resveratrol is a natural plant substance that is mainly found in red grapes, berries and peanuts. In recent years, it has been studied intensively for its potential health-promoting effects, particularly in connection with longevity.
Resveratrol acts as an antioxidant and is said to have cell-protecting effects. Of particular interest is its ability to activate so-called sirtuins - enzymes that are associated with the regulation of cell ageing and metabolic processes. Studies on animals show that under certain conditions resveratrol can trigger effects similar to calorie restriction, a known mechanism for prolonging life.
David Sinclair, one of the world's best-known ageing researchers and professor at Harvard Medical School, is one of the most prominent proponents of resveratrol. In his publications - particularly in his book “Lifespan: Why We Age - and Why We Don't Have To” - he describes resveratrol as one of the most promising substances for activating so-called “longevity genes”, especially the sirtuins.
What exactly does Sinclair say about Resveratrol?
- Activation of sirtuins According to Sinclair, resveratrol activates the enzyme SIRT1, which plays a key role in cell repair, metabolism and ageing regulation. He often compares the effect of resveratrol to that of calorie restriction - one of the few known ways to extend lifespan in animal studies.
- Resveratrol + NMN = dream team? Sinclair emphasizes that resveratrol may be particularly effective in combination with other molecules such as NMN (nicotinamide mononucleotide), as the two affect different pathways of cellular energy supply and longevity.
- Taking it yourself: Sinclair says he has been taking resveratrol daily for years (about 1 gram in the morning, together with some fat, because it is fat-soluble). However, he emphasizes that he is not making any medical recommendations and that more research is needed.
- Criticism and caution Even if Sinclair is very optimistic, there is also criticism: some other scientists point out that the effect in humans has not yet been clearly proven and that early hopes were partly exaggerated. Even Sinclair now frequently emphasizes that resveratrol is part of a larger puzzle - not the sole solution.
Conclusion
For David Sinclair, Resveratrol is an exciting part of his personal anti-aging strategy. He sees it as a potential means of activating the body's own protective mechanisms, but also warns that it is not a miracle cure - but rather a possible building block for a longer, healthier life.
Ashwagandha - the power root from Ayurveda
Ashwagandha, also known as “sleep berry” or Withania somnifera, is a medicinal plant that has been used in Ayurvedic medicine for over 3,000 years. The name translates roughly as “smell of the horse” - this is not only a reference to the earthy smell of the root, but also to the invigorating effect it is said to have.
Origin and use
Ashwagandha originally comes from India, Africa and the Middle East. In traditional Ayurvedic teachings, it is considered an adaptogen - in other words, it is said to help the body to cope better with stress and restore inner balance. The root is usually used, but the leaves are also rarely used.
Effects and benefits
The effects of ashwagandha are manifold and are particularly useful in stressful, nervous phases:
- Stress reduction & cortisol lowering - studies show that ashwagandha can lower cortisol levels - the main stress hormone. Many report better sleep, more serenity and inner peace.
- Sleep quality - The plant is traditionally used for sleep problems - especially for stress-related restlessness or difficulty falling asleep.
- Concentration & cognitive performance - There is evidence that ashwagandha can improve memory and attention - especially in people under stress.
- Boosting libido & fertility - Some studies have shown a positive effect on testosterone levels, sperm quality and sexual energy - in both men and women.
- Anti-inflammatory & antioxidant effects - Like many plant substances, ashwagandha can also fight free radicals and have an anti-inflammatory effect.
Studies
Modern research confirms many of the traditional applications. The stress-reducing effect has been particularly well investigated - randomized studies have shown that ashwagandha can significantly reduce stress and anxiety when taken regularly - in some cases comparable to mild medication, but without the typical side effects.
There is also promising data for sleep disorders, mild depression and to support cognitive performance. However, not every effect has yet been proven in large long-term studies - but the trend in research is clearly positive.
Conclusion
Ashwagandha is more than just a trend - it is a powerful medicinal plant with a long tradition and growing scientific support. Whether for calming in stressful times, for better sleep or as a natural energy booster, the root has many potential uses. If you want to rely on herbal support, ashwagandha is a proven companion.
Ergothioneine
L-Ergothioneine is a unique naturally occurring amino acid produced by mushrooms, yeasts, and certain types of bacteria.
What makes it special is that it behaves in the human body similarly to a vitamin. Vitamins are essential for us because our bodies cannot produce them on their own, yet they are needed for important biochemical reactions.
Ergothioneine acts as a powerful antioxidant and anti-inflammatory agent that protects cells from oxidative stress. For this reason, it is often referred to as the “longevity vitamin.” Studies have shown that ergothioneine levels decline as part of the aging process.
Effects and Benefits
- Antioxidant activity: Neutralises harmful free radicals (ROS) and binds pro-oxidative metals, preventing cellular damage.
- Anti-inflammatory effects: Inhibits inflammatory mediators, helping reduce inflammation.
- Cell protection: Protects cells from damage caused by oxidative stress.
- Anti-aging / Longevity support: Promotes longevity, may slow down the aging process, and protects internal organs from age-related damage.
- Skin protection: Protects the skin from UV damage, supports repair, and helps maintain moisture.
- Eye protection: Shields the lens and cornea from oxidative stress caused by UV radiation and may help prevent cataracts.
- Cognitive support: Because ergothioneine can cross the blood-brain barrier, it may have beneficial effects on the brain and support overall cognitive health.
- Metabolic support: May help promote the formation of NAD⁺, a coenzyme associated with longevity.
Conclusion
A vital compound that supports cellular function, brain health, and healthy longevity.
Taurine
Taurine is an amino acid that performs many important functions in the body, such as supporting heart health, stabilising cell membranes, and promoting fat digestion. It also acts as a strong antioxidant, detoxifying and anti-inflammatory agent, and supports the development of the brain and nervous system.
Effects and Benefits
- Heart health: Supports a regular heartbeat and influences signal transmission and the development of the heart.
- Nervous system: Acts as a neurotransmitter in the brain, protects nerve cells, has a calming effect, and is involved in the healthy development of the central nervous system.
- Digestion: Plays a role in the formation of bile acids, thereby supporting fat digestion and the absorption of fat-soluble vitamins (A, D, E, K).
- Antioxidant effects: Protects cells from free radicals and oxidative stress.
- Cell function: Helps stabilise cell membranes and regulates the influx of minerals such as calcium into cells.
- Immune system: Stimulates and supports immune function.
- Development: Important for the healthy development of the retina and photoreceptors.
Conclusion
A deficiency can lead to increased susceptibility to infections and other issues, such as growth disorders in children, weakened immunity, or retinal degeneration. As we age, taurine concentrations in the body decrease.
— Dr. Jose L. Cordeiro
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